Volume 2, Issue 1A,January 2021

Current Issues

01 - ACNE- PATHOGENESIS, TYPES, CAUSES AND REMEDIAL TREATMENT FOR ACNE

Acne, from the Greek word “Akme” means peak or apex, is genetic or acquired affections of the pilosebaceous units. The correct name for acne is Acne vulgaris. Acne is a disease that affects 80% of adolescents and young adults. Acne vulgaris is one of the most common dermatological disorders that afflict people in their adolescence. Acne vulgaris or simply known as acne is a human skin disease characterized by skin with scaly red skin (seborrhea), blackheads and whiteheads (comedones), pinheads (papules), large papules (nodules), pimples and scarring. Acne vulgaris is a disease of pilosebaceous unit characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts. Acne affects skin having dense sebaceous follicles in areas including face, chest and back. The present review focuses on an epidemiology, etiology, pathogenesis, diagnosis, and management of acne with the pharmaceutical dosage forms. Various allopathic medicines for acne treatment includes benzoyl peroxide, antibiotics, antiseborrheic medications, sulfur and sodium sulphacetamide, anti- androgen medications, salicylic acid, hormonal treatments, alpha hydroxy acid, retinoids, azelaic acid, keratolytic soaps and nicotinamide and herbal medicine like neem, tea tree oil, turmeric, raw papaya fruit, lemon, mint etc. Currently laser and light devices and minor subcision surgery have been also performed for acne treatment.

Keywords - Acne, Epidemiology, Etiology, Pathogenesis, Diagnosis, and Management of acne

Author - Balbir Singh*, Pankaj Mishra, Pushpendra Kannojia, Rohit Kumar Bijauliya and Prashant Kumar Singh

Affiliation - BIU College of Pharmacy, Bareilly International University, Bareilly-243006 (Uttar Pradesh), India

02 - FORMULATION AND EVALUATION OF NATAMYCIN NIOSOMAL GEL FOR TRANS-DERMAL DRUG DELIVERY

The present study aimed to investigate the delivery potential of Natamycin containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Mean particle size of niosomal formulation was found to be in the range of 2 μm to 4 μm. Niosomal formulation N2 (1: 1) ratio of cholesterol and surfactant displayed good entrapment efficiency (96.72%). TEM analyses showed that niosomal formulation was spherical in shape. Niosomal formulation (N2) displayed high percentage of drug release after 24 h (94.91) at (1: 1) ratio of cholesterol: surfactant. Further selected niosomal formulation was used to formulate topical gel and was characterized with respect to its various parameters such as pH, viscosity, spreadability, ex vivo study, and in vivo potential permeation. Ex vivo study showed that niosomal gel possessed better skin permeation study than the plain topical gel. Further in vivo study revealed good inhibition of inflammation in case of topical niosomal gel than plain gel and niosomal formulation. The present study suggested that topical niosomal gel formulations provide sustained and prolonged delivery of drug.

Keywords - Transdermal drug delivery, Niosome, Natamycin, Topical

Author - Prabhakar*, Devender Singh, S.K. Prajapati, Deepak Yadav, Sanju Kumari and Sonam Baghel

Affiliation - Institute of Pharmacy, Bundelkhand University, Jhansi-284128 (Uttar Pradesh), India

03 - DEVELOPMENT, CHARACTERISATION AND EVALUATION OF TOLMETIN MICROEMULSION FOR TOPICAL DELIVERY

The objective of this study was to formulate optimal formulations of microemulsions (MEs) and evaluate their feasibility for delivery of resveratrol into in-vitro skin permeation. For this purpose, initially, solubility of Tolmetin was determined in various vehicles. Solubility study was also performed for optimization of formulation. The optimized microemulsion formulation was characterized for its transparency, viscosity & pH, Drug content, dispersion study and in-vitro skin permeation study. The viscosity and pH data indicated that the microemulsion was of the o/w type. Hence, by formulating into microemulsion, the solubility of tolmetin was found to be significantly enhanced.

Keywords - Microemulsion, Tolmetin, Transdermal Drug Delivery System

Author - Shishu Pal*, Ram Narayan Prajapati and Rohit Kumar Bijauliya

Affiliation - Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi-284128 (Uttar Pradesh), India

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