03. FORMULATION AND EVALUATION OF METOPROLOL SUCCINATE CONTROLLED RELEASE TABLET BY MELT GRANULATION AND DIRECT COMPRESSION METHOD
Controlled release products are designed to maintain constant therapeutic plasma concentration of the drug within the therapeutic range of the drug over prolonged period and offer minimum side effects. This can be achieved using a variety of delivery systems. These products are designed to reduce the frequency of dosing by modifying the rate of drug absorption. The frequency of administration or the dosing interval of any drug depends upon its half-life or mean residence time (MRT). Generally controlled release products administered by any route are design such that rate of drug absorption should be equal to rate of drug elimination. Controlled release tablet of metoprolol succinate was prepared by melt granulation and direct compression method using various hydrophilic polymers of natural and synthetic grades. The tablets from all formulations were evaluated for thickness, density, weight variation and friability. The drug release was influenced by the amount of polymer incorporation in the formulation.