Abstract

02. FORMULATION AND EVALUATION OF NIOSOMAL GEL OF TIMOLOL MALEATE FOR OCULAR DRUG DELIVERY

Abstract


The main purpose of the study was to develop niosomal gel of timolol maleate with increased bioavailability (enhanced permeation) and sustained action (drug retention at the target site). Using different ratios of span 60 and cholesterol, niosomes were prepared by Hand Shaking method and optimized by evaluating different parameters like drug content, entrapment efficiency, particle size and in-vitro drug diffusion study. The niosomal pellets were further incorporated in gel, prepared by the method and further optimized by parameters like gelling parameters, mucoadhesive strength and in-vitro drug release study. The optimized niosomal formulation containing span 60 and cholesterol in equal proportion (1:1) showed better drug content (DC) i.e. 86.3±0.39% and entrapment efficiency (EE) i.e. 83.4±0.22 with vesicle size of 465±0.24 nm. The in vitro drug diffusion study indicated t90 value of 490 min thus proving sustained action of the formulation. The optimized gel containing poloxamer 407 (P407) and poloxamer 188 (P188) in the ratio of 1:2.7 showed gelation temperature at 37 0C (physiological temperature of the body) and t90 value of 10 h thus depicting sustained action. Thus, sustained drug delivery with increased bioavailability was designed for timolol maleate for the treatment of ocular disease.

    Article Information

  • Volume - Volume 2
  • Issue - Issue 2B
  • S.N - 02
  • Pages - 32-40
  • Authors - Sonam Baghel*, Devender Singh, Prabhakar and Shishu Pal
  • Affiliation - Institute of Pharmacy, Bundelkhand University, Jhansi-284128 (Uttar Pradesh), India
  • Email -
  • Types of manuscript - REVIEW ARTICLES
  • Language - English
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