7.FORMULATION AND DEVELOPMENT OF DRUG LOADED ACECLOFENAC EMULGEL FOR TOPICAL DRUG DELIVERY SYSTEM
For the delivery of hydrophobic medicines, emulgels has emerged as a promising drug delivery method. The purpose of the study was to prepare aceclofenac emulgel, an NSAID, with the use of Carbapol 934 as a gelling agent. The emulsion was prepared, and the gel base was incorporated. For rheological tests, spreading coefficient studies, power of bioadhesion, skin irritation studies, in-vitro release, ex-vivo release studies, anti-inflammatory activity and analgesic activity, the formulations were evaluated. Emulgel is one of the new NDDS technologies used for dual control release for topical use of emulsion gel. The consistency of the emulsion, when incorporeal into gel, is increased. The overall objective of the current research was the formulation and evaluation of aceclofenac emulgel. Which will improve the drug's skin penetration relative to the drug's existing commercialised preparations. In this analysis, five types of gelling agents were used to produce emulsifier formulations of aceclofenac: carbopol 934, hydroxyl propyl methyl cellulose, sodium carboxyl methyl cellulose, and sodium alginate. The release of the drug via a dialysis membrane from all gelling agents was assessed. Concerning colour, homogeneity, consistency, and pH value, all gels showed reasonable physical properties. The formulation of carbopol demonstrated superior drug release among all gel formulations than that of Na CMC, HPMC & Sodium alginate. Polymer can be used as emulsifiers and thickeners because the gelling ability of these compounds allows stable emulsions and creams to be produced by reducing surface and interfacial tension while increasing the aqueous phase's viscosity. Indeed, the presence in the water process of a gelling agent transforms a classical emulsion into an emulgel. On novel vesicular systems as well as on traditional systems, these emulgel have significant advantages in various aspects. The effect can be potentiated by different permeation enhancers, so emulgels can be used in current systems as improved topical drug delivery systems. The use of emulgels can be extended in analgesics and antifungal drugs.