17. FORMULATION AND EVALUATION OF FLOATING MICROSPHERE OF NIZATIDINE
In the last three decades, oral controlled release dosage forms have been developed due to their major therapeutic benefits, such as ease of administration of patient compliance and flexibility in formulation. These factors contributed to the production in the gastrointestinal tract of a novel orally regulated release dosage form with Gastro retentive properties. Gastro retentive dosage forms (GRDFs) will stay in the gastric region for many hours, greatly increasing the period of drugs in the gastric field. Prolonged gastric retention increases bioavailability, reduces drug loss, and improves less soluble drug solubility in a high pH environment. Floating microspheres of Nizatidine were prepared by the solvent diffusion method of evaporation. The drug was encapsulated in various Eudragit and ethanol polymer ratio combinations. The prepared microspheres are evaluated for particle size, percent buoyancy, study of in-vitro release, and stability studies. The buoyancy level was found to be between 80.22% and 88.54%. The good buoyancy behaviour of the microspheres showed that the microspheres are hollow in nature and maintained for more than 12 hours in the upper part of the GIT to improve gastric residence time. In order to ensure in vivo efficacy, the formulations prepared should be clinically tested. The current study compared the combination of polymers and revealed their effect on the release of drugs and various other parameters in floating microsphere preparation.