15. PRE-FORMULATION STUDIES FOR THE DEVELOPMENT OF LIPOSOME BASED SUSTAINED RELEASE DELIVERY SYSTEM AS ANTICANCER DRUG
To address the disadvantages of traditional drug delivery methods, there are several approaches available for the design and production of formulations for extended- release drug delivery. Such drug delivery systems are mainly intended to enhance disease control by altering the pharmacokinetic profiles of therapeutic agents usually administered as traditional tablets or capsules. Preformulation is a study which deals with the structure for the combination of drug with pharmaceutical ingredients in dosage form manufacturing. The analysis of preformulation is to create the elegant dosage form by determining the kinetic rate profile, compatibility with the other ingredients, defining the new drug 's physicochemical parameter and polymorphism. The pre-formulation also provides details on the organoleptic property, solubility, melting point and drug-related partition coefficient, drug stability, drug absorbance, and analysis of FTIR among these properties. As the 6-mercaptopurine is a very powerful medication, this medication is used by many researchers in their work. This research paper helps those people who want to use 6-mercaptopurin for development of new formulation related to this drug.