2. A REVIEW ON EXPERIMENTAL ANIMAL MODELS FOR ANXIETY DISORDERS IN RATS
Anxiety has a profound influence on both human and animal behaviour. Both the psychological and biological aspects of anxiety are needed for anxiolytic drug evaluation. Animal models are used as screening methods in the search for compounds with therapeutic potential in the field of anxiety research and as simulations for research on processes that underlie emotional actions. Animal models of anxiety have been optimised mainly for rats, with a mixed performance for mice, an easy-to-use mammal with stronger genetic possibilities than rats. We based on the most commonly used animal models for anxiety in mice in this study. To reflect all types of animal models of anxiety, both conditioned and unconditioned models are highlighted. Strong care for variable parameters, linked to climate, handling or model, is needed in behavioural studies. In order to facilitate more understanding of neurobiological aspects of anxiety, we study the latest experimental anxiety models such as elevated plus maze apparatus, light dark model, open field apparatus, holeborad apparatus.