Vol. 1, Issue 2B,December 2020
1. DEVELOPMENT OF BENZIMIDAZOLE DERIVATIVES AS TARGET BASED ANTITUMOR DRUGS: AN OVERVIEW
Cancer (also being identified as neoplasm, proliferative activity or tumours), is a world-wide uncontrolled disease affecting almost every part of the world. Cancer can be defined as the excess of reproduction of targeted cells due to abnormality in action of the molecular function or in signal transmissions. Although, various of anticancer drugs were already marketed and in applicable. Most of the drugs identified does not have selective targeted actions which directly or indirectly affects the normal cells of the targeted area. This review surveyed and studied about various of novel synthesized anticancer active drugs targeting selective interacting sites of malignant cells like hCAs, tubulin protiens, Gal-1, EGFR, and so on.
Keywords - Anticancer, Target, hCAs, Tubulin, Galectin-1, EGFR, VEGFR-2, Malignant, Benzimidazole, Hybrids
Author - Devleena Tiglani , Salahuddin , Prashant Kumar Sharma and Rajat Yadav
Affiliation - Research Scholar, Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park II, Greater Noida- 201306 (Uttar Pradesh), India
2. A REVIEW OF PHYTO-CHEMICAL CONSTITUENT AND PHARMACOLOGICAL ACTIVITY OF THUJA SPECIES
Traditional healthcare systems play an important role in our healthcare system. The villagers use this plant mainly for the treatment of various diseases. Thuja belongs to the family of cupressacae. This is commonly used in Ayurvedic medicine. There are five species in the thuja genus, three local to eastern Asia and two local to North America. Phylogenomic investigations resolved two sister sets, T. standishii- T. koraiensis and T. ocidentalis- T. sutchuenensis, with T. plicata sister to T. occidentalis-T. sutuenensis. This alternative system of medication is increasing expanding fame overall Thuja species are generally used as an antiviral, antibacterial, anti-cancer, anti-diabetic, anti-HIV, anti- fungal etc. Antiviral action and immunopharmacological action of Thuja, as stimulatory effects on cytokine and antibody production and also activate macrophages cells, have been tested in various in-vivo and in-vitro study. Thuja species have different chemical substances like thujone, isothujone, fenchone, sabines and ?-pinen. This review article provides comprehensive information on various useful and traditional medicinal properties of chemical composition and pharmacological activity of plants and their components.
Keywords - Thuja, Antiviral, Antibacterial, Anti-cancer, Anti-diabetic
Author - Mohit Gupta*, Komal Sharma, Dharmender Solanki and Rajat Yadav
Affiliation - Shri Ram Murti Smarak College of Engineering & Technology (Pharmacy), Bareilly- 243202 (Uttar Pradesh), India
3. THE ROLE OF METOPROLOL SUCCINATE IN THE TREATMENT OF HYPERTENSION: A MINI REVIEW
The main risk factor for cardiovascular disease is hypertension. Approximately a third of people with hypertension are actually undiagnosed and about half of those diagnosed are not taking antihypertensive drugs. Every year, the World Health Organization (WHO) predicts that high blood pressure causes the death of at least nine million people worldwide, directly or indirectly. The β- adrenergic blocking agent Metoprolol has long been used to treat patients with hypertension.
Keywords - Hypertension, Etiology, Hypertension diagnosis, Metoprolol succinate
Author - Sanju Kumari * , Suneel Kumar Niranjan and Prabhakar
Affiliation - Institute of Pharmacy, Bundelkhand University, Jhansi-284128 (Uttar Pradesh), India
4.A COMPREHENSIVE REVIEW ON EPILEPSY
Epilepsy is commonly known as seizure-associated medical conditions either morbid or comorbid altogether. Although many different procedures were determined for diagnosing and treating epilepsy using various methods. It is still very difficult to diagnose the exact causative path for an epilepsy occurrence. Thus, understanding epilepsy with its classifications, different pathophysiologies have helped researcher to target-selective drugs against epilepsy. Thus, this article defines epilepsy with different classes of anti-epileptic drugs describing their advantages and disadvantages of their applications.
Keywords - Epilepsy, Anti-epileptic drugs, Pathophysiology, ILAE
Author - Devleena Tiglani*, Salahuddin, Avijit Mazumder, Rajnish Kumar, Prashant Kumar Sharma and Kriti Pateriya
Affiliation - Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), 19, Knowledge Park II, Greater Noida- 201306 (Uttar Pradesh), India
5.SMART CONTROLLED RELEASE POLYMERS AS BACKBONE OF PHARMACEUTICAL DRUG DELIVERY SYSTEM: OLD WINE INTO NEW BOTTLE WITH CHALLENGES AND PROMISES
This review addressed the role of polymer in efficient delivery of active pharmaceutical ingredients. Polymers are the strength of pharmaceutical drug delivery system by controlling the release rate and solving the troubles related with API such as solubility, bioavailability and stability. Polymers play vital role in drug delivery of immediate release dosage form (tablet, capsule) and modified release dosage form (gastro retentive dosage form). Biodegradable polymers pay more attention in drug delivery because of their biocompatible, biodegradable and non-toxic character additionally it show constant release rate of drugs. Now-a-days, synthetic biodegradable polymers are preferred more because they solve the trouble regarding with natural polymer such as lot to lot variation, microbial contamination and uncontrolled rate of hydration. Smart polymers show change in response with altered environmental conditions such as pressure, pH, temperature, change in concentration and ionic strength. In this review, we have included various aspects of polymers and discussed drug release mechanism such as degradation, diffusion and swelling. The recent advances in polymeric drug delivery system include molecularly imprinted polymer (MIPs) also discussed. In addition, this review also include role of various synthetic and natural plant derived biodegradable polymers functional in drug delivery.
Keywords - Polymer, Dissolution controlled, Diffusion controlled, Biodegradable, Natural, Stimuli responsive
Author - Nidhi Singh, Rahul Shukla* and Prashant Kumar Sharma
Affiliation - Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, New Transit Campus, Bijnor Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow (UP)- 226002 (Uttar Pradesh), India (Uttar Pradesh), India
6.EVALUATION OF PHARMACOGNOSTICAL AND LAXATIVE ACTIVITY OF LEAVES OF NYCTANTHES ARBOR-TRISTIS LINN.
The aim of the “study was to evaluate the Nyctanthes arbor-tristis Linn. for its pharmacognostical properties and for its laxative activity”. Macroscopical study of Nyctanthes arbor-tristis Linn. showed that Nyctanthes arbor-tristis having light to dark green color, indistinct odor, bitter and astringent taste and heart shape, rough texture, 5-14 cm long and 2.5-5.7 cm wide size, entire margin and round base. Animal study showed that Nyctanthes arbor-tristis Linn initiates the laxative activity 0-8 hour and showed complete laxative activity on 8-16 hours, which was compared with the standard drug sodium picosulfate. Pure extract of Nyctanthes arbor-tristis was found effective as that of standard drug sodium picosulfate for the constipation in albino Wistar rats.
Keywords - Laxative activity, Nyctanthes arbor-tristis, Sodium picosulfate, Gastro-intestinal tract (g.i.t.) motility, Intestinal transit
Author - Anjali Yadav*, Rohit Kumar Bijauliya and Prashant Kumar Singh
Affiliation - Rameshwaram Institute of Technology & Management, Lucknow -243006 (Uttar Pradesh), India
7.FORMULATION AND DEVELOPMENT OF DRUG LOADED ACECLOFENAC EMULGEL FOR TOPICAL DRUG DELIVERY SYSTEM
For the delivery of hydrophobic medicines, emulgels has emerged as a promising drug delivery method. The purpose of the study was to prepare aceclofenac emulgel, an NSAID, with the use of Carbapol 934 as a gelling agent. The emulsion was prepared, and the gel base was incorporated. For rheological tests, spreading coefficient studies, power of bioadhesion, skin irritation studies, in-vitro release, ex-vivo release studies, anti-inflammatory activity and analgesic activity, the formulations were evaluated. Emulgel is one of the new NDDS technologies used for dual control release for topical use of emulsion gel. The consistency of the emulsion, when incorporeal into gel, is increased. The overall objective of the current research was the formulation and evaluation of aceclofenac emulgel. Which will improve the drug's skin penetration relative to the drug's existing commercialised preparations. In this analysis, five types of gelling agents were used to produce emulsifier formulations of aceclofenac: carbopol 934, hydroxyl propyl methyl cellulose, sodium carboxyl methyl cellulose, and sodium alginate. The release of the drug via a dialysis membrane from all gelling agents was assessed. Concerning colour, homogeneity, consistency, and pH value, all gels showed reasonable physical properties. The formulation of carbopol demonstrated superior drug release among all gel formulations than that of Na CMC, HPMC & Sodium alginate. Polymer can be used as emulsifiers and thickeners because the gelling ability of these compounds allows stable emulsions and creams to be produced by reducing surface and interfacial tension while increasing the aqueous phase's viscosity. Indeed, the presence in the water process of a gelling agent transforms a classical emulsion into an emulgel. On novel vesicular systems as well as on traditional systems, these emulgel have significant advantages in various aspects. The effect can be potentiated by different permeation enhancers, so emulgels can be used in current systems as improved topical drug delivery systems. The use of emulgels can be extended in analgesics and antifungal drugs.
Keywords - Aceclofenac, Topical Drug Delivery System, Emulgel
Author - Suman *, Shashi Bhushan Tiwari1 , Rohit Kumar Bijauliya and Prashant Kumar Singh
Affiliation - Department of Pharmaceutics, BIU College of Pharmacy, Bareilly International University, Bareilly-243006 (Uttar Pradesh), India