Volume 2, Issue 2B, March 2021,

Current Issues

01. ROLE OF ESSENTIAL OILS FOR MOSQUITO REPELLENT ACTIVITY

Depending on the sort of action they possess, plant products can be employed as insecticides to kill larval or adult mosquitoes, or as repellents to prevent mosquito bites. Man has been exploiting the repellency of plant material for thousands of years, most simply by hanging bruised plants in buildings, a technique that is still common in poorer nations. Plants have also been utilized for ages as crude fumigants, in which plants were burned to keep mosquitoes away, and later as oil formulations applied to the skin or clothing. Mosquito repellant essential oils are widely utilized. These essential oils are crucial in human existence because they help to keep mosquitoes at bay.

Keywords - Essential oil, Mosquito repellent, mosquitoes, traditional herbs

Author - Rohit Kumar Bijauliya*, Pushpendra Kannojia, Pankaj Mishra, Prashant Kumar Singh and Balbir Singh

Affiliation - BIU College of Pharmacy, Bareilly International University, Bareilly-243006 (Uttar Pradesh), India

02. FORMULATION AND EVALUATION OF NIOSOMAL GEL OF TIMOLOL MALEATE FOR OCULAR DRUG DELIVERY

The main purpose of the study was to develop niosomal gel of timolol maleate with increased bioavailability (enhanced permeation) and sustained action (drug retention at the target site). Using different ratios of span 60 and cholesterol, niosomes were prepared by Hand Shaking method and optimized by evaluating different parameters like drug content, entrapment efficiency, particle size and in-vitro drug diffusion study. The niosomal pellets were further incorporated in gel, prepared by the method and further optimized by parameters like gelling parameters, mucoadhesive strength and in-vitro drug release study. The optimized niosomal formulation containing span 60 and cholesterol in equal proportion (1:1) showed better drug content (DC) i.e. 86.3±0.39% and entrapment efficiency (EE) i.e. 83.4±0.22 with vesicle size of 465±0.24 nm. The in vitro drug diffusion study indicated t90 value of 490 min thus proving sustained action of the formulation. The optimized gel containing poloxamer 407 (P407) and poloxamer 188 (P188) in the ratio of 1:2.7 showed gelation temperature at 37 0C (physiological temperature of the body) and t90 value of 10 h thus depicting sustained action. Thus, sustained drug delivery with increased bioavailability was designed for timolol maleate for the treatment of ocular disease.

Keywords - Niosomes, niosomal gel, Sustained drug release, Ocular drug delivery, timolol maleate

Author - Sonam Baghel*, Devender Singh, Prabhakar and Shishu Pal

Affiliation - Institute of Pharmacy, Bundelkhand University, Jhansi-284128 (Uttar Pradesh), India

03. FORMULATION AND EVALUATION OF METOPROLOL SUCCINATE CONTROLLED RELEASE TABLET BY MELT GRANULATION AND DIRECT COMPRESSION METHOD

Controlled release products are designed to maintain constant therapeutic plasma concentration of the drug within the therapeutic range of the drug over prolonged period and offer minimum side effects. This can be achieved using a variety of delivery systems. These products are designed to reduce the frequency of dosing by modifying the rate of drug absorption. The frequency of administration or the dosing interval of any drug depends upon its half-life or mean residence time (MRT). Generally controlled release products administered by any route are design such that rate of drug absorption should be equal to rate of drug elimination. Controlled release tablet of metoprolol succinate was prepared by melt granulation and direct compression method using various hydrophilic polymers of natural and synthetic grades. The tablets from all formulations were evaluated for thickness, density, weight variation and friability. The drug release was influenced by the amount of polymer incorporation in the formulation.

Keywords - Controlled release tablet, Oral drug delivery system, Metoprolol succinate

Author - Sanju Kumari*, S. K. Niranjan, Prabhakar, Sonam Baghel and Deepak Yadav

Affiliation - Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University, Jhansi-284128

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